基因检测结果呈阴性可能是虚假的安慰

Consumer genetic tests could be giving false reassurance to those at heightened risk of cancers, according to findings presented at an international conference last pany Invitae, revealed that tests for breast and bopanies such as 23andMe give negative results to the vast majority of those carrying DNA mutations in the genes under investigation.这项由临床基因检测公司Invitae开展的研究显示，23andMe等直接面向消费者的公司对乳腺癌和肠癌风险的检测显示，绝大多数携带受测基因DNA突变的人检测结果都是阴性的。These tests should not be taken at face value at all, plete.“研究数据强调的是，人们需要认识到，这种检测的结果可能不会是错误的，但遗憾的是，它们是不完整的。”The research also shomon in people of Ashkenazi Jemon among individuals of northern European ancestry. The pany explains the limitations of these tests to consumers and on its petitor that pany said it makes clear to customers that it tests only for certain genetic variants and that customers should not forgo any remended testing based on 23andMe results.23andMe is not a diagnostic test, the pany said.If an individual has a family history of cancer or other indications for clinical testing mend consulting a healthcare provider first.该公司表示，已向客户明确表示，只检测某些基因变异，客户不应放弃任何基于23andMe结果的推荐检测。该公司表示：“这不是诊断测试。如果一个人有癌症家族史或其他临床检测的适应症，我们一直建议首先咨询医疗机构。”Prof Anneke Lucassen, a clinical geneticist at the University of Southampton, said that, in her experience, non-specialists panies fault but through loe to clinic ask: Have I got the gene for breast cancer? and imagine its a single test, not that the test involves looking through around 20,000 letters of the genetic code to see if any one of them might be different.她说：“我确实认为假阴性率是个问题，这不一定是由于公司的失误，而是由于人们的普遍意识不强。大多数来诊所的人会问：‘我有乳腺癌的基因吗？’想象一下，这是一个单一的测试，而不是通过检查大约两万个基因序列编码来判断哪些有所不同。”